Reversing metabolic age is no easy endeavor. There are 9 hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, deregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and altered intercellular communication. All 9 benefit from the rejuvenative and regenerative signaling content of Pluripotent stem cells and Plurisomes, since they reach all 220+ tissue types and with their secretive reprogram any nucleic and metabolic pathways that are causing degeneration. Stem cell exhaustion is especially a concern in aging. By the age of 60 we only have about 10% of our origins stores left. Pluripotent stem cells made from the patient’s own skin cells, the Autologous AESC, are a sure way to replenish these stores.
Immune dysregulation is at the root of all auto-immune diseases. All therapies must have their primary focus to re-establish immune tolerance to endogenous tissue. Pluripotent stem cells and Plurisomes have affinity to all 220+ tissue types and signal immunoregulatory molecules and transcriptions factors to help to repair and regenerate all tissues in the body. This is why we have such positive results treating autoimmune processes.
The facial nerve provides varied motor support and sensory communication in the face and nearby anatomical areas. When cranial nerve 7 becomes damaged, the symptoms are many, drooping of the mouth, inability to close the eye, dry eye, sensitivity to sound, tingling and pain, loss of taste, and entrapment neuropathies that extend to the neck and shoulders. Pluripotent stem cells and Plurisomes come in to repair the chronic nerve aggravation and damage via their neurotropic growth factors and mRNA and miRNA transcription factors.
The pancreas is such a precious organ, yet we so little talk about it. It produces natural insulin that shunts glucose into our cells for energy production. This process becomes dysregulated in excess carbohydrate intake or in diabetes type 1, an autoimmune condition where the islet cells atrophy. Pluripotent stem cells and Plurisomes come to the rescue in both cases, by immunomodulating autoimmunity processes at play, by preventing islet cell apoptosis and tissue atrophy that renders disease reversal nearly impossible.
A fracture is a traumatic injury event to the bone tissue. Bone regeneration and bone remodeling is called into play immediately and long term. Pluripotent stem cells and Plurisomes secrete immunomodulatory factors that help in the acute phase, and specific bone repair factors such as bone morphogenic factors (BMP), osteoprotegerins (OPG), that speed up the healing and prevent complications long term.
Bone spurs, also called osteophytes, form as a result of excessive bone tissue bundling, causing protuberances. Endogenous stem cells are sometimes accused of being the culprits via their accelerating bone regenerative Sox9 gene activity. Pluripotent stem cells and Plurisomes secrete reparative factors such as OPG and BMP and remodel this bone deformation, a mechanism similar to scar and keloid remodeling.
Multiple Sclerosis needs a treatment strategy that quenches aggravating chronic inflammation, halts disease progression and reverses established neural damage. Pluripotent stem cells and Plurisomes releasing immune & growth factors, neurotropic factors, mRNAs & miRNAs that signal repair and regeneration of central and peripheral nerve tissue. Pulsating doses for extended periods are recommended.
Chronic inflammation is a direct causative factor in the formation of aneurysms. The weakening of the wall is due to the degradation of extracellular matrix in the vessel wall. Pluripotent stem cells and Plurisomes secrete anti-inflammatory and immunosuppressive factors that help mitigate this damage. They also contain vascular endothelial growth factors (VEGF) and numerous angiogenic factors that directly rebuild and strengthen the blood vessel wall.
TIAs and strokes cause neurological damage due to extended periods of oxygen deprivation. This leads to inflammation, apoptosis (cell death), and long term brain tissue atrophy. Pluripotent stem cells and Plurisomes address repair on all three levels, stimulating immuno-regulation, angiogenesis and neurogenesis. They also release factors that build biobridges between the sites of injury and your own stem cells niches in the brain, waking up dormant stem cells for continual repair.
Temporary lack of oxygen transport to brain tissue causes inflammation, apoptosis (cell death), and brain tissue atrophy. The long term consequences lead to severe mental and physical disability. Long term administration of pulsating doses of Pluripotent stem cells and Plurisomes gradually rebuilds blood vessel pathways to the area (angiogenesis) and repairs neural tissue (neurogenesis).
Traumatic brain injury involves neuroinflammation, neurodegeneration and brain tissue atrophy. Pluripotent stem cells and Plurisomes secrete immunomodulatory, neurotropic factors, and create biobridges between stem cell niches and injury sites, all of which stimulates significant repair and regeneration of brain tissue.
Chronic inflammation and senescence are at the root of neurodegeneration and cognitive decline. Pluripotent stem cells and Plurisomes release into the aging tissue anti-inflammatory, immuno-regulatory, senolytic, senomodulatory, and senopreventive factors. There are 3 ways stem cells help to repair & regenerate brain tissue:
by releasing neurotropic factors, immune & growth factors, mRNAs & miRNAs that signal renewal, repair, and regeneration by waking up 'niched' stem cells and stimulating them, via formation of a neuro-vascular matrix, a biobridge between the niche and sites of senoinflammation, injury, damage and neurodegeneration by replenishing autologous stem cell stores, with AESC
The dysfunction and loss of dopaminergic neurons in Parkinson’s disease leads to serious degeneration of brain tissue and loss of function. Pluripotent stem cells and Plurisomes secrete neurotropic growth factors like NGF, BDNF, NT-3 to NT-5 that act as protective agents and assist in repair and regeneration of brain tissue.
ALS is a systemic loss of upper and lower motor neurons. Pluripotent stem cells and Plurisomes contribute systemically to the halting of disease progression and reversing the motor neuron degeneration. Neuroinflammation, denervation at neuromuscular junctions, axonal defects, loss of connectivity along the entire motor axis call for a systemic immunomodulatory, neurodegenerative strategy.
Damage to the developing brain, as in cerebral palsy (CP), causes severe mental and physical disabilities. Pluripotent stem cells and Plurisomes contain neuroregenerative signaling factors that help mitigate this developmental injury. They release a cascade of immune and growth factors and induce the release of neural stem cells within the young brain that trigger the production of new neurons and glial cells.
Fluoroquinolones cause systemic damage at the cellular level and at tissue level. The mitochondria take the brunt of the intracellular damage. Pluripotent stem cells and Plurisomes release peptides, enzymes and growth factors that help to protect mitochondrial function and energy production. The tendons and ligaments upholding all organs and limbs are the most damaged tissue. Pluripotent stem cells and Plurisomes release immunomodulatory factors and growth transcription factors that work diligently to rebuild tensile strength and flexibility of tendons and ligaments.
Pre-exisitng conditions and old age show the highest fatality in COVID-19. Immunosenecense (immune aging) is at the root of this. Chronic inflammation, excess of senescent (aging, inflammatory) cells and the extra affinity that this virus has for lung tissue and ACE2 receptors in the body - all pose an extra challenge. Pluripotent stem cells and Plurisomes secrete immunomodulatory and senolytic factors that help quench the dangerous cytokine storm and attenuate the senescent cells. Functional dysregulation and organ damage from COVID-19 infection can lead to long-term post-viral symptoms. Pluripotent stem cells and Plurisomes reach all 220+ tissue types and signal repair molecules and transcriptions factors that help to get your whole body back on tract.
Although digestion seems like a complex system where so much can go wrong, at the physiological level only three types of injury are happening: inflammation, apoptosis and atrophy. Acid Reflux, Ulcers, SIBO, IBS are all diagnoses of tissue injury due to these 3 physiological processes. Pluripotent stem cells and Plurisomes work at the cellular, tissue and organ level to downregulate excessive inflammation, to prevent unnecessary apoptosis and to reverse tissue atrophy that flattens the microvilli of the digestive tract and causes mibrobiome imbalances and symptoms of aggravation and irritability in the digestive tract.
Research is now clear that embryonic stem cells and their secretions, exosomes, create an anti-tumorigenic microenvironment. The microenvironment produced by Pluripotent embryonic stem cells suppresses tumorigenic properties, reprograms malignant cells to a benign state and de-
creases the invasiveness of cancer cells. Cancer regression is the goal in our early cancer treatment options.
Post-viral chronic fatigue requires a systemic strategy. All organ systems and functional systems need to be simultaneously involved in the repair process. Pluripotent stem cells and Plurisomes produce whole body repair and rejuvenation. They have affinity to all 220+ tissue types and signal repair molecules and transcriptions factors that help to rejuvenate the whole array of exhausted systems.
Liver damage is multifaceted, yet there are 3 processes of degeneration at play. Chronic inflammation, hepatocyte apoptosis, and whole organ atrophy. All 3 combined lead to severe liver dysfunction and at worst liver failure. Pluripotent stem cells and Plurisomes luckily address all 3 type of liver tissue damage. Interleukins, chemokines, peptides, TNFs, miRNAs present in the plurisomes all code for an anti-inflammatory microenviroment that can quelch liver inflammation. Anti-apoptotic factors
Heavy metal toxicity is more common than we think. Mercury, Lead, Aluminum, Cadmium are often times off the charts in heavy metal urine tests. Chelation with intravenous EDTA and systemic detox support is our first line of treatment. Pluripotent stem cells and Plurisomes are added to this protocol to support systemic tissue damage repair, that is significant with high levels of metal toxicity.
Neuroinflammation is one of the major causes of recurrent migraines. Pluripotent stem cells and Plurisomes are masterful at quenching inflammation in the brain for two reasons. Firstly, unlike MSC, they have high affinity to brain tissue. Secondly they are abundant in immune factors and mRNAs and miRNAs thatched for immunomodulatory changes at the cellular level.
Injury brings on inflammation. This is healthy until it becomes dysregulated or chronic. Pluripotent stem cells and Plurisomes contain immunoregulatory peptides and transcriptions factors that attenuate the runaway inflammation, and allow the body to heal without the chronic pain and aggravation. We treat joint, ligament and tendon injury with local injections of ozone followed by pluripotent stem cells and Plurisomes.
In neuropathy, damaged nervous tissue fibers co-exists side by side to healthy uninjured nervous fibers. The damaged fibers cause inflammation and aggravate the intermingling healthy fibers, leading to neuropathic pain. Pluripotent stem cells and Plurisomes release neurotropic factors like NGF, BDNF, CNTF that protect the healthy fibers and assist the regeneration of damaged nerve tissue simultaneously.
Pluripotent stem cells and Plurisomes help to prevent opioid tolerance. This allows for safe tapering while maintaining therapeutic effect for pain relief. With stem cells, opioid effectiveness is maintained at lower and lower doses and gradually the patient can get off the medication. There is also evidence that exosomes can rewire the brain’s reward and pleasure centers so the patient no longer craves the experience the drug provided. This is a safe and whole-body regenerative way to get patients off opioid addiction, and by extension numerous forms of prescription drug addiction.
Premature Ovarian Insufficiency (POI) is the cessation of ovarian function before the age of 40. It’s accompanied by amenorrhea, hypergonadotropic hypogonadism, and infertility. Pluripotent stem cells and Plurisomes release numerous peptides and transcriptions factors that help to reverse this condition and restore normal ovarian function. Anti-apoptotic factors and miRNAs prevent tissue degeneration and follicular atrophy. Angiogenic factors bring healthy blood flow and nutrients to the area, replenishing the organ.
Chemotherapy and radiation therapy are life saving to many on the cancer diagnosis spectrum. They cause damage to cancer cells and to healthy tissues simultaneously. The recovery must include systemic whole body regeneration. Pluripotent stem cells and Plurisomes have affinity to all 220+ tissue types and signal repair molecules and transcriptions factors that help to repair and regenerate the whole array of exhausted and damaged systems.
Hearing loss has a number of causes, the main being inflammatory and neurodegenerative. Pluripotent stem cells and Plurisomes tackle both simultaneously. The immune factors, like the anti-inflammatory interleukins and chemokines, modulate the immune picture of the inner ear to be less inflammatory. The neurotropic growth factors, like the BDNF, b-NGF and VEGF, set up tissue for nerve tissue repair and regeneration.
Although life-saving, surgery is a type of injury to the tissues. The body needs time to recover. Pluripotent stem cells and Plurisomes release growth factors, peptides, matrix proteins, enzymes, transcriptions factors and important intracellular signaling mediators that code for systemic tissue renewal, repair, and regeneration. It’s exactly what the body needs, pulsating doses of highly potent regenerative molecules.
Sinusitis is inflammatory in nature. Pluripotent stem cells and Plurisomes secrete anti-inflammatory and immunomodulatory factors that help resolve the immune imbalance and repair the aggravated nasal and sinus tissue. Any microbial imbalance causing this chronic aggravation is also treated with Ozone insufflation as supportive therapy.
As the skin heals, it forms lattices of collagen fibers. Dysregulated lattice formation leads to tissue bundling and fibrosis. This appears as scars and keloids. Pluripotent stem cells and Plurisomes release anti-fibrotic factor TGFß3, increase Collagen Type III ratio and inhibit formation of granulation tissue that leads to fibrosis. A healthy network of elastin and collagen fibers which creates support and elasticity in the healing tissue. This process is also at work smoothing wrinkles and lines.
Skin is the great protector. It is also the organ that shows aging first. Damage from the outside and from the inside, it all shows up on the skin. Stem cells release growth factors, peptides, matrix proteins, enzymes, transcriptions factors and important intracellular signaling mediators that code for skin tissue renewal, repair, and regeneration. Rejuvenation from the inside and the outside.
When skin tissue is damaged by sun exposure, injury or stretching, the tissue response is inflammation, apoptosis and fibrosis. These processes are healthy until they go unchecked. Plurisomes contain immunomodulatory, anti-apoptotic and anti-fibrotic factors and regenerative mRNA and miRNA that help remodel damaged tissue such as wrinkles and stretch marks and assist in laying down normal lattice of collagen fibers, which further remodels and rejuvenates the skin.
In damaged dermal tissue, inflammation and apoptosis lead to tissue degeneration and scar formation due to granulation tissue deposition. Plurisomes contain immune factors growth factors mRNAs & miRNAs that signal immunomodulation, angiogenesis, neurogenesis, anti-apoptotic and anti-fibrotic modulation that allows tissue to clear infection, clear run-away inflammation and begin the process of skin repair swiftly.
Tinnitus can involve structural and/or functional dysfunction in the brain or the auditory pathway. Pluripotent stem cells and Plurisomes contain immunomodulatory and neurotropic factors that help support repair of these tissues, often leading to resolution. Pulsating doses of local injections are recommended.
Please see our full article on vocal cord dysfunction.