Wednesday, January 19, 2022
In this blog I will discuss stem cell therapy, the different kind of stem cells used in regenerative medicine around the world, and why we work with pluripotent stem cells.
What are stem cells?
Stem cells are the building blocks of life. The somatic cell of the human body comes from human stem cells. They are found in every part of your body and play an important role in maintaining essential function of all of your organs. They signal repair and regeneration anytime there is tissue injury or a lapse in function, whether it's cardiac function or cognitive function. Anytime there is a problem, they come to the rescue of any damaged tissue and damaged cells. For this reason, the stem cell is considered the master cell of regenerative medicine.
What is stem cell therapy?
Stem cells are used in medical treatment all around the world, in clinics, in hospitals. They are harnessed to help the body to self-repair, to self-regenerate. Adult stem cell therapy is the most common in most countries, mainly due to availability and regulation. Pluripotent stem cells are also now coming to the forefront of full body repair therapeutics. These stem cell types are often called the “miracle cells” because they can signal repair in all 220+ tissue types of the body, and when autologous, they can turn into endogenous stem cells and somatic stem cells to replenish dying cells in diseased organs, including the brain cells. This ability makes them useful in treating essentially all diseases, all types of cells and tissues benefit. The therapeutic potential of stem cells is remarkable.
What are the different types of stem cells?
There are two main types of stem cells used in medical therapy:
multipotent stem cells, also called mesenchymal stem cells, adult stem cells
Adult stem cells are obtained from various tissues such as bone marrow, adipose tissue, placental tissue, umbilical tissue.
Sources of stem cells for adult stem cell therapy vary. Effective treatment has been reported with the use of adipose-derived stem cells, bone-marrow stem cells, hematopoietic stem cells, placental stem cells, umbilical stem cells, fetal stem cells. These are all mesenchymal stem cells and the stem cell pool from each source contains specialized cell types that all differ in regenerative potential. Multipotent stem cells are best suited for signaling repair in 6-8 tissue types of the body, the cartilage, the tendons, the ligaments, the bones, the skin and a few more.
pluripotent stem cells, embryonic stem cells
The embryonic stem cell is the youngest stem cell type being used in medicine now. It is known for its unmatched regenerative capacity. It gives rise to all 3 germ layers of the body, and is therefore capable of signaling repair and regeneration in all 220+ tissue types of the body.
Embryonic stem cell research shows that it's not the high proliferative capacity nor the high differentiation capacity that is of key importance in pluripotent stem cell regenerative therapy. Any stem cell doctor will concur that it's not important in clinical medicine that they have potent cell proliferation potential or that they can turn into neural stem cells, cardiac stem cells, or blood vessel cells or any cell type or cell population. That is key for research, but in clinical environments it's the unique secretome, what the stem cells secrete, that matters for tissue repair.
The signaling profile of pluripotent embryonic stem cells is very unique and specifically positioned to repair DNA damage, to elongate telomeres, to stimulate the tissue to grow new blood vessels and nerve cells, to dissolve scarring and allow the tissue to become more supple and elastic as young healthy tissue is. Epigenetic reprogramming of tissue back to a healthy metabolic profile is what embryonic stem cells do best. Due to this unique action, the therapeutic potential of embryonic stem cells is vast. Any tissue can benefit, at any stage of injury.
Where do the embryonic pluripotent stem cells from?
Embryonic stem cells come from a tissue line grown from the inner cell mass of the blastocyst. 5 days after fertilization, the embryo layers split into the inner cell mass and the outer cell mass. The outer cell mass produces the placenta. The inner cell mass contains all the information to grow and repair all tissues of the body. If you grow a stem cell line from the inner cell mass layer, it cannot create a body, but it contains the regenerative information for all 220+ tissue types of the body. This is why embryonic stem cells are so comprehensive in their tissue reach and repair.
Are embryonic stem cells the same as fetal stem cells?
No, they are very different. Fetal stem cells are much older than embryonic and already differentiated. They are multipotent. Fetal stem cells fall in the #1 category, mesenchymal stem cells. multipotent stem cells. They do not have the regenerative reach nor the unique signaling profile of pluripotency. It's a very different type of stem cell.
Why use pluripotent stem cells?
The pluripotent embryonic stem cells are by far the most comprehensive and have have powerful regenerative potential. They are capable of epigenetic reprogramming in all organs, repair damage in every tissue type, since they have the most comprehensive signaling profile for all cell types in the body. David Sinclair and his team at Harvard have backed this up with research, showing that regular pulsing doses of pluripotent signaling factors from embryonic stem cells are the key to reprogramming tissue to a younger metabolic and biological age. They have even restored sight in aged mice. If you can restore tissue and organs to a younger biological age, they can better repair and regenerate.
How do pluripotent stem cells repair the tissues and organs?
The therapeutic potential of pluripotent stem cells is mainly due to their potent paracrine effectors, exosomes, that signal repair in tissues and awaken the dormant tissue specific stem cells. Pluripotent stem cells release potent epigenetic reprogramming factors such as Yamanaka factors, NANOG. These take your 65 year old heart and turn back the clock on that tissue, allowing it to beat at healthier 36 year old level.
Analysis of the content of pluripotent secretome reveals presence of proteins, peptides, growth factors, systemic factors that repair nerve damage (neurotrophic factors, especially important in neurological disorders), that grow more blood vessels in the areas (angiogenic) , autophagy-related proteins that clear senescence (senolytic), telomore longating factors, DNA repair factors, collagen and elastin supporting factors and so on. Anything that helps the tissue to bounce back to healthy state seems so be pumped out from these unique cell types.
What are the beneficial effects?
Essential function of pluripotent stem cells is to repair and regenerate. Any damage, any injury, any disease (including degenerative diseases, neurodegenerative diseases, cardiovascular disease, liver disease, retinal disease) can benefit from the repair and regenerative potential of this cell type.
Patient results vary, depending on condition and overall vitality. We have had patients improve in heart function, liver function, cognitive function, in digestion, in pain reduction of chronic pain or joint pain, in energy levels and overall vitality. We have seen patients heal from lyme and cancer, the beneficial effects are vast. View our patient testimonials for more about this.
Are there any adverse effects?
Pluripotent embryonic stem cells are safe when administered by trained medical staff and sourced from a high-caliber reputable laboratory. Our clinic has seen no serious adverse events in over a decade of pluripotent stem cell therapy.
The only risk during administration of IVs we have found in over 15 years of clinical experience is mild hypoglycemia upon administration. The stem cells use glucose for their physiological activity. We mitigate this risk by making sure patients have had a meal before injection and are well hydrated.
How is stem cell therapy administered?
The stem cells secrete a powerful reparative, regenerative and rejuvenate cocktail into every tissue of the body. This is the reason why we administer the Pluripotent stem cells intravenously, and locally via direct injection, so that they can travel into every tissue of the body.
Can the body reject stem cells?
Essential function of allogenic stem cells is to scan the tissue and release a reparative secretome. Once they have done this, they are cleared by the immune system within 24-48 hours. If you receive autologous pluripotent stem cells, these remain in the body, replenish the depleted stem cell pool, and continue to signal repair long term.
Why go to Cabo, Mexico to get stem cell therapy?
Cabo is a wonderful place to combine travel & relaxation with physical & emotional healing. Cabo's natural beauty is breathtaking. Its people are warm-hearted and fun-loving. The food is healthy, streets are safe and businesses open and welcoming.
Biological regenerative medicine, like pluripotent stem cell therapeutics, requires favorable regulatory and legal conditions to thrive and innovate. Mexico has a visionary government, its laws permitting and not prohibiting leading-edge human stem cell therapeutics, human stem cell research and international medical and stem cell tourism. Also, the cost of high quality medical care in Mexico is often times less expensive.
Our Stemaid Institute in Cabo is a very special place. It's the only clinic in the world where you can receive pluripotent stem cells and pluripotent exosomes in your wellness protocols. The clinic is beautiful, the staff are attentive, the doctors and nurses deeply caring. Healing here is very pleasant and peaceful.