Parkinson's disease is a chronic neurodegenerative disease that affects especially motor function and movement. The symptoms include tremors, stiffness, involuntary movement, and difficulty walking.
People suffering with Parkinson's disease are facing 3 main challenges:
Regenerative medicine in the form of pluripotent stem cell therapy for Parkinson's disease patients aims to restore function of the brain cells and dopaminergic cells, replenish neurochemical pathways to improve dopamine release, reactivate neural progenitor cells, grow healthy stem cell-derived dopamine neurons, and signal whole body repair in each individual patient. Although environmental factors and genetic risk factors may play a role in advanced disease, pluripotent stem cell signaling and the reparative sequelae can make a big difference.
Stemaid programs are 2-5 weeks in length, depending on your condition and severity of your symptoms. Every candidate for stem cell therapy receives a customized plan to help achieve the highest success rate, however, a "typical" plan for the treatment of patients with this condition might include the following over 4 weeks of daily treatment followed by 6 months of weekly treatment.
20 stem cell IVs
4 Plurisomes IVs
Benefits of stem cell therapy for neurological diseases vary depending on stem cell approaches and the severity of the condition. At Stemaid Institute, we utilize the most comprehensive pluripotent cells. These type of cell replacement therapies are unique in that they signal repair in all parts of the body, and can repair the nerve tissue in the brain and in the periphery, including dopamine-producing neurons, restore balance amongst immune cells and help recover the lost cognitive and motor function.
Because we utilize stem cell types that we can culture in our laboratory, instead of extracting adult human mesenchymal stem cells (adult stem cells), bone marrow stem cells, we completely avoid the potential risk factors or adverse events associated with these cellular therapies.
With pluripotent stem cell treatments, it is possible to achieve neurological recovery of functional neurons and dopaminergic neurons and recovery of body and motor function. With each injection, repair mechanisms are triggered and the patient's brain starts to produce new connections and reactivation of neural stem cells.
One of the key beneficial effects of stem cell treatment is immune regulation. The immunomodulatory effects of hESC treatment are critical in easing symptoms. Pluripotent stem cells and exosomes release transcription factors that help immune cells to shift away from TH1 autoimmune reactivity. Detoxification IVs and anti-parasite treatments also assist the healing. This calms the fire in the brain and allows for dopamine-producing neurons to repair and grow.
The second level of therapeutic effects is usually observed after a minimum of 3-4 weeks, when inflammatory fire is quenched and the dopamine neurons begin heal. The neuron is a complex cell, and the human dopamine neuron requires time to regenerate. Over time, the tremors, rigidity, instability and bradykinesia begin to show sign of easing. Motor fluctuations can occur from day to day, but overall motor scores steadily improve.
A major challenge in healing from Parkinson's is improving quality of life. This condition is disabling both cognitively and physically. Current treatments in regenerative medicine do their best in supporting patients in living better longer with this condition. Pluripotent cells release their signaling factor molecules for months post-treatment, and work on reprogramming all tissues for self-repair. As motor function improves, and cognition ameliorates, the patients become once again more independent and quality of life improves.
hESC treatment with pluripotent factors, like the one being utilized at Stemaid Institute, is now recognized as the most potent whole body repair and rejuvenation treatment strategy. The effects are seen gradually, with highest protective effects between 12 to 180 days post treatment. This is a long term treatment. The epigenetic reprogramming that occurs with pluripotent cellular therapies is the next frontier in regenerative medicine for neurological disorders.
In addition to our standard line, autologous cell transplants of pluripotent stem cells is also possible with Stemaid Laboratories Autologous Pluripotent Stem Cell line. These type of human cells are produced from your own human fibroblasts and contain your own DNA, and thereby graft well. These type of transplanted cells lead to formation of autologous stem cell-derived dopamine neurons in the brain, considered the most potent and long lasting solution.
Initial studies and preclinical studies show promise in treatment of neurological conditions, even in advanced disease. Motor scores and cognitive scores steadily improve in neurological disease in patients seen at Stemaid Institute.
The current status of Stemaid stem cell clinical trial options is pretrial. Clinical studies and human trials using pluripotent stem cells will initially assess markers of biological aging. The epigenetic reprogramming that occurs with this type of disease-modifying treatment has direct positive effect on aging mechanisms we believe will directly shed light on brain health, motor function and treatment of neurological diseases. Environmental factors and genetic factors, although fraught with logistical challenges, and how these affect the success of pluripotent stem cell therapies are also of interest in future study designs.