Wednesday, March 01, 2023
Regenerative Medicine
In contrast to current clinical strategies, which are primarily concerned with treating symptoms, regenerative medicine is focused on replacing tissues, cells or organs that have been compromised by disease or trauma. The methods used to achieve these results include tissue engineering, cellular therapies, medical devices, and artificial organs.
When we are injured or infected with disease, our bodies are designed to respond, heal and defend. But what if we can improve our bodies own healing ability and speed up the process?
Regenerative treatments aim to repair damaged tissues and organs. Researchers are also working on treatments for organs that have been permanently damaged. The goal of this methodology is to find a way to treat injuries and diseases that were previously considered incurable.
Stem cell therapies treat the underlying cause of pain rather than relieving it with medication or surgery, resulting in increased function and mobility with a shorter recovery time than surgical options. The health benefits of this therapy can cover various conditions; to promote healing in the body, stem cells can differentiate into various types of cells to replace damaged cells.
Stem Cell Patches vs Stem Cell Therapy
Stem cell treatments have been used for years in various medical practices. Hematopoietic stem cell transplant, or bone marrow transplant, is used to treat blood cell disorders such as leukemia and lymphoma. Stem cell patches are a new technology based on stem cell therapy.
Stem Cells
Pluripotent stem cells can communicate with all cells in your body in order to regenerate the designated target.
Our pluripotent stem cells, unlike adult stem cells, can express the DNA of all 220+ types of cells in the body. As a result, they have an unrivaled ability to heal and restore youth in all organs.
Pluripotent stem cells can be delivered through the bloodstream or directly to the organ in need of repair, depending on the circumstances.
Pluripotent exosomes also function in ways other than releasing the recipient's adult stem cells. They include anti-inflammatory, anti-fibrotic, and growth factors, as well as senolytic agents. Pluripotent stem cells and their exosomes have the most potent effects for treating degenerative conditions.
Injections
Injections are shown to help treat various medical conditions such as heart disease or MS, and are also used for general promoted health including:
- Mental clarity
- Faster wound healing
- Sports performance faster recovery
- Greater overall energy
- Improved skin appearance
- Immune system support
Phototherapy patches
Phototherapy patches are a product that has been developed in attempt to increase stem cell production. The patches are usually made of organic amino acid crystals that are activated by the heat of the skin producing infrared light. This light wave reflects back and is thought to stimulate peptides that in turn activate body's stem cell activity and promote cellular repair in the area. Some phototherapy patches have been clinically proven to support wound healing, reduce minor aches and pains, promote a healthy inflammatory response, boost energy, and improve sleep.
These patches are considered an adjunctive therapy for people receiving stem cell injections or undergoing stem cell activation. Photolight therapy and photobiomodulation are techniques for promoting regeneration and supporting the body's natural healing processes.
It's important to note that these patches do not contain stem cells, there are no single cells involved. It's strictly light based activation. Light therapy differs from stem cell therapy. Manufacturers note that by reflecting particular wavelengths of light these patches can promote health and treat chronic neurological problems, improve fatigue, and aid in depression.
Naturally occurring adult stem cells are "activated" in case of trauma, cell death or a need for new cells. It's important to note that other than stem cell injections or transfusions, there is no clinically proven way to stimulate stem cells. More studies are needed.
Heart Patches
"Heart patches" are a newly researched bio-technology that has not yet been used in mainstream medical treatment. A few researchers have grown heart cells in a lab with the goal of repairing damaged hearts.
The patches are made of heart tissue, and contain up to 50 million stem cells that are programmed to be working heart muscle cells. In theory, this patch would be implanted in a patient to heal or prevent damage to the heart.
Doctors are working to develop this treatment to heal cardiovascular disease. Clinical studies are being run, but there is no access to this treatment in public medical care. Like other stem cell treatments, this implant would support damaged cells and promote cell healing or growth.
Stem Cell Therapy for Heart Failure
Heart failure is the leading cause of death worldwide, and current traditional treatments only slow the disease's progression. Clinical trials show that cell-based therapies can improve cardiac function, and the implications for cardiac regeneration are promising.
Cardiac regeneration is a broad effort that uses cutting-edge science, such as stem cell and cell-free therapy, to repair irreversibly damaged heart tissue. Reparative tools have been developed to use the body's natural ability to regenerate to restore damaged heart tissue and function. Human induced-pluripotent stem cell-derived cardiac cells (HiPSC-derived cardiac cells) are showing promise in improving recovery from heart failure events in animal models already. More research is needed.
The function of stem cells in cardiac health is to repair damaged tissue, heart and other affected organs, improve circulation, and prevent cardiovascular disease.
Benefits include:
- Reduce future risk of a heart attack
- Improved physical stamina
- Reduced circulatory congestion
Stemaid programs last between 2 and 5 weeks, depending on your condition and the severity of your symptoms. Every candidate for stem cell therapy receives a customized plan to help achieve the highest success rate.
FREQUENTLY ASKED QUESTIONS:
What are the different types of stem cells used in medicine?
Pluripotent embryonic stem cells (ESCs) are derived from the inner cell mass of a blastocyst and have the potential to differentiate into any cell type in the body. In contrast, mesenchymal stem cells (MSCs) are found in many adult tissues, including bone marrow, adipose tissue, and umbilical cord blood, and can differentiate into various types of cells within a specific lineage such as bone, cartilage, or fat cells.
Human induced-pluripotent stem cell types (hiPSCs) are generated by reprogramming adult cells, typically skin or blood cells, to an embryonic-like state by introducing specific genes. These cells have the ability to differentiate into various cell types, similar to ESCs, and are an attractive alternative to ESCs due to ethical considerations and potential for personalized medicine.
One key difference between these cell types is their origin. ESCs are derived from embryos, while MSCs and hiPSCs are obtained from adult tissues. Additionally, ESCs and hiPSCs have a greater differentiation potential than MSCs, which are limited to differentiating into a specific lineage. However, MSCs and hiPSCs are more readily available for clinical use than ESCs due to the ethical considerations surrounding the use of embryonic tissue. Ultimately, the choice of stem cell type depends on the intended application and the specific characteristics required for the desired outcome. Human induced-pluripotent stem cell and its overall cell viability for clinical use has not been established yet. More studies are needed.
How are stem cells being used to treat health conditions?
Stem cells hold tremendous potential in the field of regenerative medicine and have been studied extensively for their ability to repair damaged tissues and organs, including the heart. One of the most promising applications of stem cell therapy is in the treatment of heart disease, which remains a leading cause of death in the United States. Incidence of heart failure events is increasing all over the globe.
Heart disease encompasses a range of conditions that affect cardiac function, including hypertrophic cardiomyopathy, dilated cardiomyopathy, and ischemic cardiomyopathy, among others. Stem cell therapy has shown promise in improving cardiac function in patients with these conditions.
One of the ways stem cells can improve cardiac function is by promoting the regeneration of cardiac tissue. Studies have shown that stem cells can differentiate into cardiac myocytes, the cells that make up the heart muscle, and integrate into existing cardiac tissue. Additionally, stem cells can stimulate the growth of new blood vessels, which can improve blood flow to the heart and promote healing.
Another way stem cells can improve cardiac function is by enhancing electrical coupling between cardiac myocytes. This can reduce the incidence of ventricular fibrillation, a life-threatening arrhythmia that can lead to sudden cardiac death.
Stem cell therapy has also shown promise in improving diastolic function, which is impaired in many patients with heart failure. In a clinical trial, patients with chronic heart failure who received stem cell therapy had significant improvements in diastolic function, as measured by echocardiography and invasive hemodynamic testing with heart catheterization.
In addition to improving cardiac function, stem cell therapy has also been shown to reduce the mortality rate in patients with heart failure. In a study of patients with diastolic heart failure, stem cell therapy reduced mortality by 50% compared to placebo. Furthermore, improvements in cardiac function were observed months after treatment, suggesting that the benefits of stem cell therapy may be long-lasting.
References
1. Biological Responses of Stem Cells to Photobiomodulation Therapy - PubMed
2. Large Cardiac-muscle Patches Engineered from Human Induced-pluripotent Stem-cell–derived Cardiac Cells Improve Recovery from Myocardial Infarction in Swine
3. Clinical Outcomes of Autologous Stem Cell–Patch Implantation for Patients With Heart Failure With Nonischemic Dilated Cardiomyopathy
4. Tissue-engineered human embryonic stem cell-containing cardiac patches: evaluating recellularization of decellularized matrix
5. Stem cells, pluripotency and nuclear reprogramming
6. Induction of pluripotent stem cells from adult human fibroblasts by defined factors - PubMed