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Ovarian Rejuvenation with Stem Cell Therapy

Ovarian Rejuvenation with Stem Cell Therapy

Tuesday, October 26, 2021

What is ovarian rejuvenation?

Ovarian rejuvenation is a term used to describe the process of reversing the effects of premature  menopause and premature aging on ovarian function. It's an umbrella term for rejuvenative and regenerative medical strategies that aim to slow down aging of ovaries, avert ovarian decline and improve overall ovarian function.

Ovarian tissue regeneration is especially key for women trying to get pregnant. Fertility clinic and fertility center programs mostly focus on improving ovarian hormone production, improving ovarian response, supporting follicle development, oocyte quality, oocyte yield, and oocyte retrieval for successful pregnancy. 

The impact of hormone therapy can yield successful pregnancy, yet there are several additional ways to augment ovarian rejuvenation therapy for fertility in women whose ovulatory function is vastly depleted. Fertility specialists can use ultrasound guided intra-ovarian injections of platelet-rich plasma, peptides and growth factors.

Recently, intravenous application and ovarian injection of stem cells and their tissue regeneration rich secretome, exosomes, are showing promising results in early-stage clinical trials and in clinical practices helping women improve their chances of pregnancy. Stem cells support the peri-menopausal human ovary and the aged ovary by introducing regenerative and reprogramming factors into the tissue and rebooting organ function. Stem cells and exosomes are the next frontier in ovarian rejuvenation therapy. 

What is premature ovarian insufficiency (POI)?

Primary ovarian insufficiency (POI) is a condition where women lose ovarian reserve and their ability to produce quality and quantity of eggs. It is also known as premature ovarian failure. POI affects approximately 1% of women worldwide. Some women lose their egg reserves quite early, in their 30's and early 40's. The reasons for this relatively early decline are many — family history, hormonal dysregulation, autoimmunity, toxins, stress. Most doctors will agree that the solutions are not simple. Fertility treatments for successful pregnancy in these women can be challenging. 

How can stem cell therapeutics help treat POI?

Stem cells secrete potent regenerative proteins and transcription factors that when injected into the blood stream, or via direct injection into the vicinity of the ovary or via intraovarian injection, they stimulate the quiescent ovarian stem cells to reactivate organ function and overtime, the ovarian tissue resumes its ovulatory function. Pluripotent stem cells are especially potent for ovarian reactivation. Their exosomes, Plurisomes, contain dozens of many ovarian specific transcription factors that reboot cell proliferation and follicular development . Intravenous and ovarian injection of these potent ovarian tissue reprogramming factors allows the layer of tissue to heal, to regenerate and to restart healthy organ function in women. Ovarian reactivation is the pinnacle of stem cell-based reproductive medicine. 

Desiree, Ovarian Rejuvenation Success Story

Desirèe, 39, came to the Stemaid Institute after having lost her period in the fall of 2020. Her gynecologist ran a full serum blood panel, only to discover her blood work showing POI, her ovulatory function in decline. In addition, with her serum levels of sex hormones completely depleted, she was showing symptoms of menopause. Her endovaginal ultrasound showed uterine atrophy. This all came as a shock to her, she is overall very healthy, ovarian tissue was always healthy. A menopause transition before 40 was not okay.

Desirèe with pet dog.

Her dream to be a mom, to have a healthy pregnancy some day.

These symptoms of menopause hit her hard. Her functional medical team told her that there is not much that can be done, the elevated serum level of follicle-stimulating hormone (FSH) was just too high to turn this around. She was quickly losing hope. So she came to us, knowing that we offer ovarian rejuvenation procedures using pluripotent stem cells.

Ovarian Stem Cell Therapy

At Stemaid Institute, we designed an ovarian rejuvenation program for Desirèe, with weekly intravenous injections of exosomes derived from Pluripotent stem cells, Plurisomes™, and direct injection of these regenerative factors into the uterine and ovarian areas. After 4 weeks, we ran the blood work again — and her POI was gone! Her blood values returned back to healthy normal. A week later, she called us with great news, her menstrual cycle was back as well. 6 months later, her cycle days are still regular. What a relief for everyone! 


Author: Dr Denisa Rensen

Denisa Rensen, BSc (Double Honours Biology & Philosophy), BA (Clinical Psychology), ND (Naturopathic Medicine), FAARM (Fellowship in Anti Aging & Regenerative Medicine, A4M)

Denisa is Medical Director of the Stemaid Institute, a medical and research center focusing on degenerative conditions, age reversal medicine, and pluripotent stem cells.

Her expertise in anti-aging and regenerative medicine is creatively fused with her passion for optimal living, consciousness expansion, and futurism. Denisa has lectured and spoken on many conferences, among others she presented at Humanity+ TransVision 2019 in London, Annual Healthy Masters International Conferences in Porto Portugal, and Age Reversal Conference Series in Hawaii, Stockholm and Luxembourg.